USPTO Patents Application 09993647

Appl. No. 09/993,647

Reply to Office Action of, January 29, 2007

Listing of Claims:

This listing of claims will replace all prior versions, and listings, of claims in the application:
1.-73. (Canceled)

74. (Currently Amended) A method for the treatment of a solid tumor in a human or

animal comprising administering

N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea er-

N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4 (2 (N methylcarbamoyl) 4
pyridyloxy)phenyl) urea

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-carbamoyl-4-pyridyloxy) phenyl)

urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula :

H H

or a pharmaceutically acceptable salt thereof .
75.-80. (Canceled)

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81. (Currently Amended) A method for the treatment of a carcinoma, myeloid

disorder or adenoma in a human or animal comprising administering

N ( 4 chloro 3 (trifluoromethyl)phenyl) N' ( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea or

N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4 (2 (N methylcarbamoyl) 4

pyridyloxy)phenyl

A^-(4-chloro-3-(trifluoromethyl) phenyl)-iV'-(4-(2-carbamoyl-4-pyridyloxy) phenyl)
urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula:

H H

or a pharmaceutically acceptable salt thereof .
82.-86. (Canceled)

87. (Currently Amended) A method for the treatment of carcinoma of the lung, pancreas,
thyroid, bladder or colon in a human or animal comprising administering
N ( 4 chloro 3 (trifluoromethyl)phenyl) N' ( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea or
N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4 (2 (N methylcarbamoyl) 4

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pyridyloxy)phenyl

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^-(4-(2-carbamoyl-4-pyridyloxy) phenyl)
urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula :

H H

or a pharmaceutically acceptable salt thereof .
88.-92. (Canceled)

93. (Currently amended ) A method as in claim 8 1 for the treatment of myeloid
leukemia or villous colon adenoma .

94-98. (Canceled)

99. (Currently Amended) A method of claim 74 wherein a human in need thereof is
treated.

100. (Currently Amended) A method of claim 87 for the treatment of carcinoma of the
lung in a human in need thereof .

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101. (Currently Amended) A method of claim 87 for the treatment of carcinoma of the
pancreas in a human in need thereof .

102. (Currently Amended) A method of claim 87 for the treatment of carcinoma of the
thyroid in a human in need thereof .

103. (Currently Amended) A method of claim 87 for the treatment of carcinoma of the
bladder in a human in need thereof .

104. (Currently Amended) A method of claim 87 for the treatment of carcinoma of the
colon in a human in need thereof .

105. (Canceled)

106. (Currently Amended) A method for the treatment of a solid tumor in a human or
animal comprising administering a tosylate salt of N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4
(2 (N methylcarbamoyl) 4 pyridyloxy)phenyl) urea orN ( 4 chloro 3 (trifluoromethyl)phenyl)
N' ( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-carbamoyl-4-pyridyloxy) phenyl)

urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula:

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H H

107. (Currently Amended) A method for the treatment of a carcinoma, myeloid disorder or
adenoma in a human or animal comprising administering a tosylate salt of N ( 4 chloro 3
(trifluoromethyl)phenyl) N'( 4 (2 (N methylcarbamoyl) 4 pyridyloxy)phenyl) urea — or N ( 4
chloro 3 (trifluoromethyl)phenyl) N' ( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-carbamoyl-4-pyridyloxy) phenyl)

urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula ;

H H

108. (Currently Amended) A method for the treatment of carcinoma of the lung,
pancreas, thyroid, bladder or colon in a human or animal comprising administering a tosylate salt
of N ( 4 chloro 3 (trifluoromethyl)phenyl) N' ( 4 (2 (N methylcarbamoyl) 4 pyridyloxy)phenyl)

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urea or

N ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4 (2 carbamoyl 4 pyridyloxy)phenyl)
urea

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^-(4-(2-carbamoyl-4-pyridyloxy) phenyl)
urea of the formula:

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula:

H H

109. (Currently Amended) A method as in claim 107 for the treatment of myeloid
leukemia or villous colon adenoma .

1 10. (Currently Amended) A method of claim 106 wherein a human in need thereof is
treated.

111. (Currently Amended) A method of claim 108 for the treatment of carcinoma of
the lung in a human in need thereof .

112. (Currently Amended) A method of claim 108 for the treatment of carcinoma of
the pancreas in a human in need thereof .

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113. (Currently Amended) A method of claim 108 for the treatment of carcinoma of
the thyroid in a human in need thereof .

114. (Currently Amended) A method of claim 108 for the treatment of carcinoma of
the bladder in a human in need thereof .

115. (Currently Amended) A method of claim 108 for the treatment of carcinoma of
the colon in a human in need thereof .

116. (Canceled)

117. (Currently Amended) A method for inhibiting RAF-kinase in a human or

mammal comprising administering a tosylate salt of an N ( 4 chloro 3 (trifluoromethyl)phenyl)

N'( 4 (2 carbamoyl 4 pyridyloxy)phenyl) urea orN ( 4 chloro 3 (trifluoromethyl)phenyl) N'( 4

(2 (N methylcarbamoyl) 4 pyridyloxy)phenyl) urea

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-carbamoyl-4-pyridyloxy) phenyl)
urea of the formula:

i i

H H or

A^-(4-chloro-3-(trifluoromethyl) phenyl)-A^'-(4-(2-(A^-methylcarbamoyl)-4-pyridyloxy)
phenyl) urea of the formula :

H H

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118 . (New ) A method as in claim 81 for the treatment of villous colon adenoma.

119. (New) A method as in claim 107 for the treatment of villous colon adenoma.

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